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Modeling and Simulations of Olfactory Drug Delivery with Passive and Active Controls of Nasally Inhaled Pharmaceutical Aerosols
Published on: May 20, 2016
[Three dimensional reconstruction of the nasal cavity structure and numerical simulation of airflow]
Xiuzhen Sun1, Shen Yu, Yingxi Liu
1Department of Otorhinalaryngology, Dalian Medical University, Dalian 116023, China.
Abstract:
The nasal cavity structure of one patient was reconstructed by the method of surface rendering based on his CT images. In a respiratory period the change of air flux in the nasal cavity was supposed based on the tidal volume and the respiratory period gained by statistical method. The digital simulation and the analysis of the airflow in the nasal cavity was made by the FEA method and the result was compared with the data from literatures. The comparison indicates that the result is confident. From the result we can observe the airflow distribution quantitatively in the nasal cavity in the period of respiration.
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