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Updated: Jul 17, 2026
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Published on: February 23, 2015
Delayed release particles from vascular endothelial growth factor for repairing spinal cord ischemic injury of rats
Yang Chen1, Feng Li, Jian-de Xiao
1Department of Orthopaedics, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, and Shenzhen Second People's Hospital, Shenzhen Guangdong, China. chyang@public.szonline.net
Objective:
To study the effect of delayed release particles from vascular endothelial growth factor (VEGF) on the reparation of ischemic injury of spinal cord in rats.
Methods:
The spinal cord ischemia model of rats was established. The delayed release particles from VEGF were injected via the intubation of spinal subarachnoid space. The rehabilitation was observed by the assessment of unfold claw reflection, space between toes, spinal evoked potential (SEP) and motor evoked potential (MEP).
Results:
VEGF prompted SEP and MEP appearance, improved the motor function of hind limbs.
Conclusions:
VEGF can promote the rehabilitation of spinal cord ischemic injury of rats.
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