Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Voltage-sensitive Na+ channels: motifs, modes and modulation.

M Stephan1, W S Agnew

  • 1Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06510.

Current Opinion in Cell Biology
|August 1, 1991
PubMed
Summary

Recent advancements illuminate voltage-dependent sodium channel structure and function, revealing complex gating modes and unknown modulatory factors beyond basic activation and inactivation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The International Guideline for the Definition, Classification, Diagnosis and Management of Urticaria.

Allergy·2026
Same author

Scaling and networking a modular photonic quantum computer.

Nature·2025
Same author

Standardized evaluation of the quality and persuasiveness of mobile health applications for diabetes management.

Scientific reports·2022
Same author

One-day diagnosis for hepatobiliary and pancreatic lesions: An innovative patient-centered care pathway organization.

Journal of visceral surgery·2018
Same author

Measurement of the Radiation Energy in the Radio Signal of Extensive Air Showers as a Universal Estimator of Cosmic-Ray Energy.

Physical review letters·2016
Same author

Cut to the chase: a review of CD26/dipeptidyl peptidase-4's (DPP4) entanglement in the immune system.

Clinical and experimental immunology·2016

Area of Science:

  • Molecular biology
  • Neuroscience
  • Biophysics

Background:

  • Significant progress in understanding voltage-dependent sodium channels (Nav channels).
  • Focus on structural organization and functional properties like activation, ion conductance, and inactivation.
  • Electrophysiological studies indicate more complex channel behaviors.

Purpose of the Study:

  • To detail recent progress in Nav channel research.
  • To highlight newly discovered complex functional properties.
  • To identify areas for future investigation regarding modulatory factors.

Main Methods:

  • Review of recent structural and functional studies on Nav channels.
  • Analysis of electrophysiological data revealing complex gating.

Related Experiment Videos

  • Identification of emerging questions in Nav channel modulation.

    • Main Results:

    • Detailed understanding of Nav channel activation, ion conductance, and inactivation.
    • Discovery of at least two distinct Nav channel gating modes.
    • Evidence for the existence of unidentified factors modulating Nav channel function.

    Conclusions:

    • Nav channel research has advanced significantly in structural and functional aspects.
    • New electrophysiological findings reveal complex gating mechanisms.
    • Further research is needed to identify and characterize novel modulatory factors influencing Nav channel activity.