Related Experiment Video

Updated: Jul 17, 2026

Large Animal Model for Evaluating the Efficacy of the Gene Therapy in Ischemic Heart
06:07

Large Animal Model for Evaluating the Efficacy of the Gene Therapy in Ischemic Heart

Published on: September 2, 2021

Gene therapy and stem cell therapy for cardiovascular diseases today: a model for translational research

Valentin Fuster1, Javier Sanz

  • 1The Zena and Michael A Wiener Cardiovascular Institute and The Marie-Josee and Henry R Kravis Center for Cardiovascular Health, Mount Sinai School of Medicine, New York, NY 10029-6574, USA. valentin.fuster@mssm.edu

Nature Clinical Practice. Cardiovascular Medicine
|January 19, 2007
PubMed

Insights

Clinical trials for myocardial regeneration show limited success, highlighting the need for translational research. Further basic science understanding of progenitor cells is crucial for advancing cardiovascular regenerative therapy.

Area of Science:

  • Cardiovascular Research
  • Regenerative Medicine
  • Translational Science

Background:

  • Clinical trials investigating myocardial regeneration therapies report neutral or minimally beneficial outcomes.
  • Disappointing results necessitate a stronger connection between basic research and clinical applications.

Purpose of the Study:

  • To emphasize the importance of translational research in cardiovascular regenerative therapy.
  • To advocate for a return to basic science research to understand underlying mechanisms.

Main Methods:

  • Review of clinical trial outcomes for myocardial regeneration.
  • Analysis of the translational pathway exemplified by restenosis therapy development (sirolimus).
  • Identification of knowledge gaps in progenitor cell and growth factor mechanisms.

Main Results:

  • Current myocardial regeneration therapies offer limited clinical benefit.
  • Translational research, like that for restenosis, can yield significant therapeutic advancements.
  • A deeper understanding of cellular mechanisms is lacking.

Conclusions:

  • Further basic research into progenitor cells and stimulating factors is essential.
  • Without enhanced fundamental knowledge, cardiovascular regenerative therapy's potential may not be realized.
  • A bidirectional approach between laboratory and clinic is vital for progress.

More Related Videos

Gene Transfer for Ischemic Heart Failure in a Preclinical Model07:35

Gene Transfer for Ischemic Heart Failure in a Preclinical Model

Published on: May 15, 2011

Generation of Human Cardiomyocytes: A Differentiation Protocol from Feeder-free Human Induced Pluripotent Stem Cells13:18

Generation of Human Cardiomyocytes: A Differentiation Protocol from Feeder-free Human Induced Pluripotent Stem Cells

Published on: June 28, 2013

Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...