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The effect of methamphetamine on serotonin and its metabolite in the suprachiasmatic nucleus: a microdialysis study
N Ozaki1, D Nakahara, Y Kasahara
1Department of Psychiatry, Nagoya University School of Medicine, Japan.
Journal of Neural Transmission. General Section
|January 1, 1991
Abstract:
The suprachiasmatic nucleus (SCN) has been identified as a major circadian pacemaker. Methamphetamine has been shown to modify the behavior of circadian rhythms. We detected extracellular serotonin (5-HT) and its metabolite 5-hydroxyindoleacetic acid (5-HIAA) in the SCN in freely moving rats, using a microdialysis method, to investigate biochemical effects of methamphetamine in the SCN. Methamphetamine infusion into the SCN dose-dependently increased extracellular 5-HT and decreased extracellular 5-HIAA.