Feto-maternal cell trafficking: a transfer of pregnancy associated progenitor cells

The embryonic and fetal development in the maternal uterine environment implies that different population of fetal progenitors must be in close contact to the maternal tissues. Accordingly, fetal mesenchymal and hematopoietic stem and progenitor cells have been described in the placenta and the fetal blood. Seeding in the maternal circulation, fetal progenitor cells can be detected in the circulation of pregnant women during most pregnancies. Decades after delivery, fetal CD34+ or mesenchymal stem cells are still detectable in maternal circulation or bone marrow. Recent studies point to the possibility for fetal progenitor cells persisting after pregnancy to home to maternal injured tissue and to adopt various phenotypes. Fetal cells in various maternal tissues can express epithelial, hepatocytic, hematopoietic, renal, cardiomyocytic, glial, or neuronal markers in human as well as mouse models. This apparent multipotency has been attributed to a fetal population of stem/progenitor cells acquired by the mother during pregnancy, named the pregnancy-associated progenitor cells. We will discuss the possible origins of this cell population and review the most recent data suggesting that these fetal microchimeric cells may participate in maternal tissue regeneration processes.