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Treatment of Osteochondral Defects in the Rabbit's Knee Joint by Implantation of Allogeneic Mesenchymal Stem Cells in Fibrin Clots
Published on: May 21, 2013
Cord-blood mesenchymal stem cells and tissue engineering
1Institute of Reconstructive Plastic Surgery, Laboratory of Vascular Tissue Engineering and Microvascular Research, New York University, New York, NY, USA. cetrulo4@hotmail.com
Stem Cell Reviews
|January 24, 2007
Summary
Cord-blood stem cells offer new therapeutic potential for connective tissue repair. This review explores their use in tissue engineering, focusing on vascularized constructs for regenerative medicine.
Area of Science:
- Regenerative Medicine
- Biomaterials Science
- Stem Cell Biology
Background:
- Mesenchymal stem cells (MSCs) from bone marrow and adipose tissue are clinically established.
- Cord-blood-derived stem cells are a newly identified, promising source for nonhematopoietic stem cell therapies.
- Injured or diseased connective tissues present a significant challenge for current treatments.
Purpose of the Study:
- To review the potential of mesenchymal stem cells (MSCs) for tissue engineering applications.
- To highlight novel strategies for creating vascularized tissue engineering constructs.
- To explore the use of cord-blood-derived MSCs as a therapeutic resource.
Main Methods:
- Review of current literature on mesenchymal stem cells (MSCs) and tissue engineering.
- Focus on strategies for vascularizing engineered tissues.
- Exploration of cord-blood as a source for MSCs.
Main Results:
- Cord-blood is an untapped resource for nonhematopoietic stem cell therapies.
- Mesenchymal stem cells (MSCs) show significant potential in tissue engineering.
- Microvascular free flaps offer a novel strategy for vascularized tissue constructs.
Conclusions:
- Cord-blood-derived mesenchymal stem cells (MSCs) represent a valuable resource for regenerative medicine.
- Vascularized tissue engineering constructs hold promise for repairing connective tissue defects.
- Further research into cord-blood MSCs can advance therapeutic strategies for tissue replacement.
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