Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Resting Potential Decay

Resting Potential Decay

The resting membrane potential of a neuron (-70mV) is sustained due to the selective ion permeability of the membrane. At the resting potential, the membrane is slightly permeable to ions like sodium (Na+) and chloride (Cl−) and highly permeable to potassium ions (K+). Differences in the ions' concentration inside the cell compared to the outside are maintained by membrane transport proteins like channels and pumps.
At rest, the K+ is the main ion that moves across the membrane through...

Resting Potential Decay

Resting Potential Decay

The resting membrane potential of a neuron (-70mV) is sustained due to the selective ion permeability of the membrane. At the resting potential, the membrane is slightly permeable to ions like sodium (Na+) and chloride (Cl−) and highly permeable to potassium ions (K+). Differences in the ions' concentration inside the cell compared to the outside are maintained by membrane transport proteins like channels and pumps.
At rest, the K+ is the main ion that moves across the membrane through...

Mismatch Repair

Mismatch Repair

Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The contribution of dynamics to macaque body and face patch responses.

NeuroImage·2023

Same author

Mental Imagery Follows Similar Cortical Reorganization as Perception: Intra-Modal and Cross-Modal Plasticity in Congenitally Blind.

Cerebral cortex (New York, N.Y. : 1991)·2018

Same author

Task-free spectral EEG dynamics track and predict patient recovery from severe acquired brain injury.

NeuroImage. Clinical·2018

Same author

Offenders become the victim in virtual reality: impact of changing perspective in domestic violence.

Scientific reports·2018

Same author

Clear signals or mixed messages: inter-individual emotion congruency modulates brain activity underlying affective body perception.

Social cognitive and affective neuroscience·2016

Same author

The perception of emotion in body expressions.

Wiley interdisciplinary reviews. Cognitive science·2015

Search research articles

Related Experiment Video

Updated: Jul 17, 2026

Assessment and Communication for People with Disorders of Consciousness

Assessment and Communication for People with Disorders of Consciousness

Published on: August 1, 2017

Mismatch negativity predicts recovery from the vegetative state.

V J M Wijnen¹, G J M van Boxtel, H J Eilander

¹Tilburg University, Department of Psychology and Health, Cognitive and Affective Neuroscience Laboratory, Warandelaan 2, 5000 LE Tilburg, The Netherlands.

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology

|January 24, 2007

Summary

Mismatch negativity (MMN) brain responses increase with recovery from the vegetative state, predicting improved auditory processing and communication. MMN can track and predict recovery from the vegetative state after severe brain injury.

More Related Videos

SECONDs Administration Guidelines: A Fast Tool to Assess Consciousness in Brain-injured Patients

SECONDs Administration Guidelines: A Fast Tool to Assess Consciousness in Brain-injured Patients

Published on: February 6, 2021

Virtual Reality Tools for Assessing Unilateral Spatial Neglect: A Novel Opportunity for Data Collection

Virtual Reality Tools for Assessing Unilateral Spatial Neglect: A Novel Opportunity for Data Collection

Published on: March 10, 2021

Related Experiment Videos

Last Updated: Jul 17, 2026

Assessment and Communication for People with Disorders of Consciousness

Assessment and Communication for People with Disorders of Consciousness

Published on: August 1, 2017

SECONDs Administration Guidelines: A Fast Tool to Assess Consciousness in Brain-injured Patients

SECONDs Administration Guidelines: A Fast Tool to Assess Consciousness in Brain-injured Patients

Published on: February 6, 2021

Virtual Reality Tools for Assessing Unilateral Spatial Neglect: A Novel Opportunity for Data Collection

Virtual Reality Tools for Assessing Unilateral Spatial Neglect: A Novel Opportunity for Data Collection

Published on: March 10, 2021

Area of Science:

Neuroscience
Clinical Neurophysiology

Background:

Mismatch negativity (MMN) is an automatic auditory event-related brain response.
MMN is a known predictor of emergence from coma and recovery from the vegetative state (VS) in the acute phase after severe brain injury.

Purpose of the Study:

To examine MMN during recovery from the vegetative state.
To assess the prognostic value of MMN in predicting recovery to consciousness and long-term outcomes in VS patients.

Main Methods:

Ten vegetative patients were monitored bi-weekly for an average of 3.5 months.
MMN amplitudes and latencies were analyzed in relation to recovery and compared to a healthy norm group.
The prognostic value of MMN for predicting recovery and functional outcome was investigated.

Main Results:

MMN amplitudes increased with recovery to consciousness.
A sudden MMN amplitude increase correlated with the emergence of inconsistent behavioral responses to commands, resembling responses in the norm group.
Initial MMN amplitude and latency predicted subsequent recovery and outcome.

Conclusions:

Auditory stimulus deviance processing ability increases with recovery from VS.
Enhanced MMN amplitude preceded overt communication, suggesting neural network consolidation.
MMN is valuable for tracking and predicting recovery from the vegetative state.