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Related Concept Videos

Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
Imaging Studies VII: Vascular Imaging01:19

Imaging Studies VII: Vascular Imaging

DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...

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Related Experiment Video

Updated: Jul 17, 2026

Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair
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Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair

Published on: September 7, 2017

Imaging angiogenesis.

Lawrence W Dobrucki1, Albert J Sinusas

  • 1Animal Research Laboratories, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, PO Box 208017, 3FMP, New Haven, CT 06520-8017, USA.

Current Opinion in Biotechnology
|January 24, 2007
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Imaging new blood vessel formation (angiogenesis) is crucial for assessing ischemia in diseases like peripheral arterial disease. Advances in hybrid SPECT-CT and PET-CT imaging offer new ways to visualize and evaluate treatments for angiogenesis.

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Area of Science:

  • Cardiovascular Imaging
  • Molecular Imaging
  • Vascular Biology

Background:

  • Angiogenesis, the formation of new capillaries, is vital in ischemia response.
  • Peripheral arterial disease and myocardial infarction involve critical angiogenic processes.
  • Risk stratification for arterial occlusive disease can benefit from angiogenesis imaging.

Purpose of the Study:

  • To highlight advancements in noninvasive imaging strategies for assessing angiogenesis.
  • To discuss the role of novel targeted imaging agents and technologies.
  • To evaluate the potential of these imaging approaches in patient risk stratification and therapeutic evaluation.

Main Methods:

  • Utilizing dedicated hybrid SPECT-CT and PET-CT systems.
  • Employing agents targeted at molecular markers of angiogenesis.
  • Incorporating receptor-probe interactions and reporter gene technology for molecular imaging.

Main Results:

  • Technological advances have enabled significant progress in noninvasive angiogenesis imaging.
  • Targeted molecular imaging agents provide new insights into angiogenic processes.
  • Hybrid imaging systems offer enhanced visualization capabilities.

Conclusions:

  • Novel targeted approaches for imaging angiogenesis are complementary to standard physiological imaging.
  • These advanced imaging strategies are crucial for evaluating therapeutic interventions aimed at promoting angiogenesis.
  • Noninvasive angiogenesis imaging holds significant value for patient risk stratification in arterial occlusive diseases.