Correlation between various cell-surface antigens induced by murine leukemia virus in the rat: serological analysis

Analysis based on the cytotoxicity test using antisera produced in rats indicated the presence of various cell-surface antigens on the tumors in WKA/Mk rats induced or artificially infected by Friend, Rauscher or Gross viruses. Each line of the tumor was found to have a common antigen, namely group-specific cell-surface antigen. A Gross type-specific and Friend and Rauscher type-specific cell-surface antigens were also detected, in keeping with the observations in the mouse system. In addition, the present experiments strongly suggested that a Friend strain-specific antigen was detected only on the cell-surface of the tumors in WAK/Mk rat induced or artificially infected by Friend virus. These results were in parallel with the data of previously reported transplantation studies.