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Microscopic colitides: a single center experience in Mexico.

Alberto Rubio-Tapia¹, Julio Martínez-Salgado, Jorge García-Leiva

¹Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (INNSZ), Vasco de Quiroga 15, Sección XVI. Tlalpan, 14000 Mexico City, Mexico. albertorubio.md@gmail.com

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Summary

This study details microscopic colitis in Mexican patients, finding diarrhea, weight loss, and abdominal pain as common symptoms. Most treated patients achieved remission, highlighting its treatable nature.

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Area of Science:

Gastroenterology
Pathology

Background:

Microscopic colitis presents with chronic diarrhea and subtle mucosal changes.
This study focuses on the clinical and histological characteristics of Mexican patients diagnosed with microscopic colitis.

Purpose of the Study:

To describe the clinical and histological features of microscopic colitis in a Mexican cohort.
To contribute to the understanding of this uncommon colonic disease in a specific population.

Main Methods:

Retrospective analysis of 26 cases from a 10-year pathology database.
Histopathological criteria reassessment and clinical data extraction from medical records.

Main Results:

The median age at diagnosis was 56.5 years, with a female predominance (1.8:1 ratio).
Diarrhea (100%), weight loss (84%), and abdominal pain (69%) were the most frequent symptoms.
Associated autoimmune diseases, particularly thyroid disorders, were noted in 61% of patients; drug-induced cases were suspected in 46%.

Conclusions:

Microscopic colitis is rare, accounting for less than 1% of colonic mucosal biopsies at the institution.
This represents the largest case series of microscopic colitis in the Mexican population to date.
The majority of treated patients experienced improvement or remission, indicating therapeutic efficacy.