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Childhood Ki-1 lymphoma: presentation as a buttock mass
S S Winter1, M H Duncan, E Foucar
1Department of Pediatrics, University of New Mexico, School of Medicine, Albuquerque 87131.
The American Journal of Pediatric Hematology/Oncology
|January 1, 1991
Summary
This case report details an unusual childhood Ki-1 lymphoma presentation as a buttock mass. Early diagnosis and combination chemotherapy led to complete remission, expanding knowledge of Ki-1 lymphoma clinical presentations.
Area of Science:
- Pediatric Oncology
- Hematopathology
- Clinical Genetics
Background:
- Ki-1 lymphoma, a rare large-cell anaplastic non-Hodgkin's lymphoma, typically affects young individuals.
- Common presentations involve localized skin and lymph node infiltration.
- Early diagnosis is crucial for effective treatment and improved patient outcomes.
Observation:
- An unusual case of childhood Ki-1 lymphoma presented as a buttock mass in an eight-year-old girl.
- Pathologic evaluation confirmed characteristic lymphoma cells expressing Ki-1 antigen (CD-30) and other markers.
- Diagnostic techniques included HLA-DR, interleukin 2 (CD-25) expression, T-cell gene rearrangement, and cytogenetic analysis revealing t(2;5).
Findings:
- The patient achieved complete remission after receiving combination chemotherapy.
- The successful treatment highlights the efficacy of current therapeutic strategies for Ki-1 lymphoma.
- This case demonstrates a rare clinical manifestation of the disease.
Implications:
- This report broadens the recognized clinical spectrum of Ki-1 lymphomas in children.
- It underscores the importance of integrating routine pathology with specialized diagnostic methods for soft-tissue masses.
- Accurate diagnosis through comprehensive evaluation is vital for effective pediatric cancer management.
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