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Three-phase CFD analytical modeling of blood flow
Jonghwun Jung1, Ahmed Hassanein
1Mathematics and Computer Science Division, Argonne National Laboratory, 9700 S. Cass Avenue, Argonne, IL 60439, USA. jungjh@anl.gov
This study simulates blood cell behavior in disturbed arterial flow using a novel three-phase model. It reveals leukocyte accumulation in low WSS regions, crucial for understanding atherogenesis and vulnerable plaque formation.
Area of Science:
- Biomedical Engineering
- Computational Fluid Dynamics
- Cardiovascular Science
Background:
- Atherogenesis is linked to blood cell behavior in disturbed arterial flow.
- The distribution of red blood cells (RBCs) and leukocytes in these regions is not fully understood.
Purpose of the Study:
- To numerically simulate hemodynamics and blood cell distribution in disturbed arterial flow.
- To investigate the relationship between wall shear stress (WSS) and cell behavior.
Main Methods:
- A three-phase computational fluid dynamics (CFD) model simulating plasma, RBCs, and leukocytes.
- Inclusion of a non-Newtonian viscosity model across a physiological hematocrit range.
- Tracking of WSS, phase distributions, and flow patterns without dispersion coefficients.
Main Results:
- Computed migration and segregation of blood cells in disturbed flow regions.
- Favorable comparison of results with existing experimental data.
- Correlation of higher leukocyte concentration with low WSS near stenotic regions.
Conclusions:
- The three-phase CFD model accurately predicts blood cell behavior in disturbed flow.
- Leukocyte accumulation in low WSS areas is influenced by flow-dependent RBC-leukocyte interactions.
- This hemodynamic analysis offers insights into vulnerable plaque formation in complex arterial flows.
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