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Postdischarge nutrition of preterm infants: more questions than answers
1Division of Neonatology, University of Tennessee Center for Health Sciences, 853 Jefferson Avenue, Memphis, TN 38163, USA. rcooke@utmem.edu
Insights
Preterm infants experience growth issues post-discharge. Nutrient-enriched formulas and supplementation may improve growth, but further research on duration and complementary feeding is needed for optimal infant nutrition.
Area of Science:
- Neonatology
- Pediatric Nutrition
- Growth and Development
Background:
- Postnatal growth retardation is common in preterm infants, worsening with immaturity.
- Standard term formulas are inadequate for preterm infants' rapid growth needs post-discharge.
- Breastfed preterm infants show poorer growth than formula-fed counterparts, highlighting a potential need for supplementation.
Purpose of the Study:
- To address the nutritional support needs of preterm infants after hospital discharge.
- To investigate the optimal composition and duration of postdischarge formulas.
- To explore the role of nutrient supplementation for breastfed preterm infants and the impact of complementary feeding.
Main Methods:
- Review of existing studies on preterm infant feeding post-discharge.
- Analysis of growth outcomes comparing standard term formula, nutrient-enriched formula, and breastfeeding.
- Identification of research gaps regarding supplementation and complementary feeding.
Main Results:
- Nutrient-enriched formulas show growth benefits when fed longer (>/=6 months corrected age).
- Shorter durations of enriched formula (=2 months corrected age) show no growth advantage.
- Breastfed preterm infants may benefit from nutrient supplementation, similar to term infants.
Conclusions:
- Optimal nutritional strategies for preterm infants post-discharge remain unclear.
- Further research is crucial to determine ideal formula composition, duration, and the role of supplementation.
- The impact of complementary feeding on preterm infant growth requires investigation.
Abstract:
Postnatal growth retardation is inevitable in preterm infants, the more immature the infant the greater the degree of postnatal growth retardation at hospital discharge. After hospital discharge, several studies have shown that growth is poorer in preterm infants fed a standard term formula than those fed a nutrient-enriched infant formula. This is not surprising because term formulas are designed to meet the requirements of the term infant, not the more rapidly growing preterm infant. After hospital discharge, breastfed infants do not grow as well as their formula-fed counterparts. Yet, there are no randomized controlled trials comparing growth in breastfed infants who did and did not receive nutrient supplementation. If mature human milk is designed to meet the needs of the term infant then breastfed preterm infants may also benefit from nutrient supplementation. Questions persist about nutritional support of preterm infants after discharge. What is the ideal composition of a postdischarge formula? Given the wide heterogeneity in nutritional status of preterm infants at hospital discharge and the difference in growth rates and composition between girls and boys, it is not clear that one formula can or will meet the nutritional needs of all infants. Studies in which infants were fed a nutrient-enriched formula to >/=6 months' corrected age show the most consistent advantage while those in which the nutrient-enriched formula was fed to =2 months' corrected age had no effect on growth. Whether this is a reflection of the duration of feeding or not is unclear. Further studies are needed to examine this issue. To date, little attention has focused on the role and/or effects of complimentary feeds these infants. Complimentary feeds will confound the effects of any study examining postdischarge growth in preterm infants. However, they may also be an important adjunct in meeting nutritional needs of these high-risk infants. Further studies are also needed to examine this issue.
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