Related Experiment Video
Updated: Jul 17, 2026
12:45
Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
Published on: December 11, 2017
Cardiac resynchronization therapy or atrio-biventricular pacing-what should it be called?
John G F Cleland1, Mansour Nasir, Ahmed Tageldien
1Department of Cardiology, Castle Hill Hospital, University of Hull, Kingston upon Hull HU16 5TX, UK. j.g.cleland@hull.ac.uk
Nature Clinical Practice. Cardiovascular Medicine
|January 25, 2007
Summary
Atrio-biventricular pacing improves heart function and reduces mortality in heart failure patients. However, cardiac resynchronization may not be the sole mechanism driving these benefits, suggesting broader therapeutic effects.
Area of Science:
- Cardiology
- Biomedical Engineering
Background:
- Cardiac dyssynchrony can reduce heart efficiency and worsen heart failure.
- Atrio-biventricular pacing (BiV pacing) has shown promise in improving cardiac function and patient outcomes.
Purpose of the Study:
- To examine the evidence supporting cardiac resynchronization as the primary mechanism for BiV pacing benefits.
- To investigate potential unknown mechanisms contributing to BiV pacing's efficacy.
Main Methods:
- Review of recent studies and randomized controlled trials on BiV pacing.
- Analysis of patient data regarding cardiac dyssynchrony and treatment response.
Main Results:
- BiV pacing significantly improves cardiac synchrony, function, symptoms, and exercise capacity.
- Conventional measures of cardiac dyssynchrony are poor predictors of BiV pacing benefit.
- Correction of dyssynchrony explains only a portion of the observed benefits.
Conclusions:
- While cardiac resynchronization contributes to BiV pacing benefits, other unknown mechanisms are likely involved.
- Withholding BiV pacing in eligible patients without imaging-confirmed dyssynchrony may be inadvisable.
More Related Videos
Related Concept Videos
01:29Disturbances in Heart Rhythm
Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...
01:25Dysrhythmias VI: Management of Dysrhythmias
Dysrhythmia management involves a multifaceted approach, incorporating pharmacological treatments, medical procedures, surgical interventions, lifestyle modifications, and patient education.Pharmacological ManagementAntiarrhythmic Drugs:Class I (Sodium Channel Blockers): This class includes quinidine and procainamide, which reduce the speed of impulse conduction in the heart, stabilize the cardiac membrane, and control arrhythmias. Quinidine and procainamide are Class IA agents that prolong the...
01:25ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias
Arrhythmia is a condition characterized by an irregular heart rhythm, with ECG changes that differ based on its origin and nature. The types of arrhythmias discussed below include atrial, junctional, and ventricular arrhythmias.Atrial ArrhythmiasPremature Atrial Complexes (PACs): PACs are early atrial beats caused by stress, caffeine, alcohol, electrolyte imbalances, hypoxia, hyperthyroidism, or certain medications (e.g., bronchodilators and decongestants). The ECG shows early P waves with an...
01:29Cardiomyopathy V: Interprofessional Care
Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
01:23Cardiopulmonary Resuscitation III: AED Use
Introduction to AEDAn Automated External Defibrillator (AED) is a portable medical device that analyzes the heart's rhythm and, if necessary, delivers an electrical shock to help the heart re-establish an effective rhythm during sudden cardiac arrest (SCA). SCA occurs when the heart suddenly and unexpectedly stops beating, leading to a loss of blood flow to the brain and other vital organs. In such emergencies, time is of the essence, and using an AED, combined with Cardiopulmonary...
01:30Cardiomyopathy II: Dilated Cardiomyopathy
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...