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Related Experiment Videos

Excursions along the Interface between Disruptive and Stabilizing Selection.

J Felsenstein1

  • 1Department of Genetics, University of Washington, Seattle, Washington 98195.

Genetics
|November 1, 1979
PubMed
Summary
This summary is machine-generated.

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Natural selection on polygenic traits can lead to specialized or generalized phenotypes. A bimodal fitness function related to breeding value favors specialization, especially with higher heritability.

Area of Science:

  • Evolutionary biology
  • Quantitative genetics

Background:

  • Polygenic traits under natural selection can evolve towards specialized or generalized phenotypes.
  • Fitness functions can be complex, such as mixtures of Gaussian curves.

Purpose of the Study:

  • To determine the conditions favoring specialized versus generalized phenotypes under natural selection.
  • To investigate the role of heritability and fitness function shape in evolutionary outcomes.

Main Methods:

  • Approximate multivariate normal distribution methods were used.
  • Numerical iterations of four-locus models were performed.
  • Algebraic analysis of a symmetric two-locus model was conducted.

Main Results:

  • A bimodal fitness function of breeding value is the condition for evolving a specialized phenotype.

Related Experiment Videos

  • Higher heritability increases the likelihood of evolving a specialized phenotype.
  • Normal approximation methods were generally supported by model iterations and analysis.

    • Conclusions:

    • The shape of the fitness function, particularly its bimodality concerning breeding value, dictates evolutionary specialization.
    • Heritability is a key factor influencing the direction of evolutionary response under disruptive selection.