Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Thrombolysis, left ventricular function, and mortality.

D P de Bono1

  • 1University of Leicester Department of Cardiology, Glenfield General Hospital, U.K.

Journal of Cardiovascular Pharmacology
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Concepts in acute coronary syndromes.

Singapore medical journal·2001
Same author

Plasminogen activator and plasminogen activator inhibitor gene expression in human saphenous vein organ culture.

Experimental and molecular pathology·2001
Same author

Inhibition of vascular smooth muscle cell adhesion and migration by c7E3 Fab (abciximab): a possible mechanism for influencing restenosis.

Cardiovascular research·2000
Same author

In vitro evaluation of c7E3-Fab (ReoPro) eluting polymer-coated coronary stents.

Cardiovascular research·2000
Same author

Inhibition of platelet thrombosis using an activated protein C-loaded stent: in vitro and in vivo results.

Thrombosis and haemostasis·2000
Same author

Galectin 1 is involved in vascular smooth muscle cell proliferation.

Cardiovascular research·2000

Coronary thrombolysis effectively treats heart attacks by restoring blood flow. This review examines how reperfusion impacts heart function and methods to assess heart muscle damage.

Area of Science:

  • Cardiology
  • Cardiovascular Medicine
  • Interventional Cardiology

Background:

  • Coronary thrombolysis is an established treatment for acute myocardial infarction.
  • The mechanisms by which thrombolysis improves outcomes, specifically restoring coronary patency and preserving myocardial function via reperfusion, remain subjects of ongoing research and debate.

Purpose of the Study:

  • To discuss the impact of coronary reperfusion on ventricular function following thrombolysis.
  • To evaluate the limitations of current methods used to assess myocardial salvage.
  • To explore the implications of these limitations for the design and interpretation of future clinical trials.

Main Methods:

  • This report is a review and discussion of existing literature and concepts.
  • It synthesizes current understanding of reperfusion physiology and assessment techniques.

Related Experiment Videos

Main Results:

  • Reperfusion following thrombolysis has significant effects on ventricular performance.
  • Existing techniques for quantifying myocardial salvage have inherent limitations that can affect study outcomes.
  • These limitations necessitate careful consideration in the design of future clinical investigations.

Conclusions:

  • Understanding the effects of reperfusion on ventricular function is crucial for optimizing thrombolytic therapy.
  • Addressing the limitations in assessing myocardial salvage is essential for advancing the field and conducting robust clinical studies.