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Related Experiment Video

Updated: Jul 17, 2026

Investigating Mammalian Axon Regeneration: In Vivo Electroporation of Adult Mouse Dorsal Root Ganglion

Investigating Mammalian Axon Regeneration: In Vivo Electroporation of Adult Mouse Dorsal Root Ganglion

Published on: September 1, 2018

Internodal function in normal and regenerated mammalian axons.

M Moldovan¹, C Krarup

¹Division of Neurophysiology, Institute of Medical Physiology, Panum Institute, University of Copenhagen, Copenhagen, Denmark. m.moldovan@mfi.ku.dk

Acta Physiologica (Oxford, England)

|January 26, 2007

Summary

Regenerated peripheral nerves have shorter internodes, impairing axonal function and energy reserves. This study reveals persistent abnormalities in regenerated human nerves, impacting long-term recovery.

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Related Experiment Videos

Last Updated: Jul 17, 2026

Investigating Mammalian Axon Regeneration: In Vivo Electroporation of Adult Mouse Dorsal Root Ganglion

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Published on: September 1, 2018

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Published on: June 13, 2017

Genetic Study of Axon Regeneration with Cultured Adult Dorsal Root Ganglion Neurons

Genetic Study of Axon Regeneration with Cultured Adult Dorsal Root Ganglion Neurons

Published on: August 17, 2012

Area of Science:

Neuroscience
Regenerative Medicine
Cellular Biology

Background:

Peripheral nerve injury leads to Wallerian degeneration, yet axons can regenerate.
Despite regeneration capacity, clinical outcomes are often poor.
Previous studies noted short regenerated internodes without clear functional impact.

Purpose of the Study:

To investigate the role of internodes in axonal function after nerve regeneration.
To determine if axonal function is permanently compromised in regenerated nerves.
To examine internodal function in regenerated human nerves.

Main Methods:

Review of experimental evidence on internodal contribution to axonal excitability.
Analysis of axonal function in regenerated nerve models.
Investigation of internodal function in human nerve samples.

Main Results:

Evidence suggests permanently compromised axonal function in regenerated nerves.
Internodal function is abnormal in regenerated human nerves.
Shorter regenerated internodes correlate with increased sodium-potassium pump activity.

Conclusions:

Persistently short regenerated internodes increase Na+/K+-pump activity due to heightened Na+ influx during conduction.
Impaired axonal function during repetitive activity and drained energy reserves may result from these changes.
Abnormal internodal function contributes to unsatisfactory clinical outcomes in nerve regeneration.