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Related Experiment Videos

Flagellin gene sequence evolution in Salmonella.

Chloe K B Mortimer1, Saheer E Gharbia, Julie M J Logan

  • 1Centre for Infections, Health Protection Agency, 61 Colindale Avenue, Colindale, London NW9 5EQ, UK. chloe.mortimer@hpa.org.uk

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
|January 26, 2007
PubMed
Summary
This summary is machine-generated.

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Salmonella flagellins, crucial for tracking infections, reveal evolutionary insights. G-group flagellins likely originated from a common ancestor with E. coli, with variations possibly driven by dual flagellin genes.

Area of Science:

  • Microbiology
  • Evolutionary Biology
  • Bacteriology

Background:

  • Salmonella flagellins (70 serotypes) are vital for infection diagnosis and tracking.
  • Flagellin terminal sequences serve as conserved evolutionary markers in bacteria.

Purpose of the Study:

  • To investigate the evolutionary origins of Salmonella flagellin serotypes.
  • To understand the mechanisms driving the emergence of new Salmonella serotypes.

Main Methods:

  • Comparative analysis of flagellin terminal protein sequences.
  • Phylogenetic clustering of G-group and Non-G-group Salmonella flagellins with Escherichia coli.

Main Results:

  • G-group flagellins exhibit distinct terminal sequences, clustering closer to Escherichia coli than other Salmonella antigens.

Related Experiment Videos

  • Evidence suggests G-group flagellins were inherited from a common ancestor shared by E. coli and Salmonella.
  • Increased flagellin variation in rare biphasic G-group serotypes indicates a role for the second flagellin locus in G-group flagellin mutation.
  • The FljB flagellin likely resulted from a single duplication of a Non-G gene, followed by synonymous mutations.

    • Conclusions:

    • G-group flagellins represent an ancient antigen set in Salmonella, potentially inherited from a common ancestor with E. coli.
    • Dual flagellin loci may facilitate G-group flagellin evolution and diversification.