Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Diamond and biology.

Christoph E Nebel1, Dongchan Shin, Bohuslav Rezek

  • 1Diamond Research Center, AIST, Central 2, Tsukuba, Japan. christoph.nebel@aist.go.jp

Journal of the Royal Society, Interface
|January 26, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Crystallinity and optical properties of Cu<sub>2</sub>FeSn<sub>3</sub>S<sub>8</sub>thin films prepared by pulsed laser deposition.

Journal of physics. Condensed matter : an Institute of Physics journal·2026
Same author

Radiative Defects in Chloride-Activated CdSe Thin Films.

ACS energy letters·2026
Same author

Computational analysis of visible frequency plasmonic properties of graphene on wide band gap heterostructures.

Scientific reports·2026
Same author

Asparagine-modified magnetic graphene oxide as efficient green nanocatalyst for synthesis of chromenes and pyrano pyrazoles derivatives.

Scientific reports·2025
Same author

Enhanced Antitumor Immunity by ASP1570, a Novel Diacylglycerol Kinase ζ Inhibitor, Offers a Potential Novel Immunotherapy for Treating Cancer.

Molecular cancer therapeutics·2025
Same author

[Analysis of hospitalization status by major classification according to ICD-10 among public assistance recipients considering sex and age].

[Nihon koshu eisei zasshi] Japanese journal of public health·2024
Same journal

RNA-ligand complexes and the attenuation of neutral confinement in the evolution of RNA secondary structures.

Journal of the Royal Society, Interface·2026
Same journal

Individual detachment-reintegration events in homing pigeon flocks and the dominance of directional adjustment in their kinematic features.

Journal of the Royal Society, Interface·2026
Same journal

Thermal stress disrupts symbiotic fluid dynamics in bobtail squid.

Journal of the Royal Society, Interface·2026
Same journal

Distinct geometrical landscapes distinguish between modes of tristability in gene regulatory networks.

Journal of the Royal Society, Interface·2026
Same journal

Slow modulation of the contraction patterns in Physarum polycephalum.

Journal of the Royal Society, Interface·2026
Same journal

Moo-ving mountains: grazing agents drive terracette formation on steep hillslopes.

Journal of the Royal Society, Interface·2026
See all related articles

Surface modifications on diamond films enable covalent bonding of molecular layers for DNA immobilization. These modified diamond surfaces facilitate the development of DNA sensors and field-effect transistors with high DNA densities and specific binding characteristics.

Area of Science:

  • Materials Science
  • Surface Chemistry
  • Nanotechnology

Background:

  • Single-crystalline diamond films offer unique electronic and chemical properties.
  • Surface modification is crucial for functionalizing diamond for biosensing applications.
  • Covalently bonded organic layers provide a stable platform for biomolecule immobilization.

Purpose of the Study:

  • To investigate photo- and electrochemical surface modifications on diamond films.
  • To characterize the formation and properties of amine and phenyl linker molecular layers.
  • To demonstrate the immobilization of single-stranded DNA (ss-DNA) and its application in biosensors.

Main Methods:

  • Surface modification via photo- and electrochemical methods.
  • Characterization using X-ray photoelectron spectroscopy (XPS), atomic force microscopy (AFM), and cyclic voltammetry.

Related Experiment Videos

  • DNA immobilization using thiol-modified ss-DNA and cross-linker molecules.
  • AFM scratching and fluorescence microscopy for DNA density and stability analysis.

    • Main Results:

    • Amine and phenyl layers exhibit distinct formation, growth, and molecular arrangements.
    • Amine layers form sub-monolayers on H-terminated diamond, while phenyl layers show multilayer growth.
    • Immobilized ss-DNA achieves densities up to 10(13) cm(-2) with a tilt angle of ~35 degrees.
    • DNA-phenyl linker bonds show higher removal forces (~75 nN) compared to DNA-amine linker bonds (~45 nN).

    Conclusions:

    • Surface modification strategies enable controlled covalent attachment of molecular linkers on diamond.
    • Diamond-based platforms can be functionalized for high-density DNA immobilization.
    • The developed system shows potential for DNA sensor and field-effect transistor applications.