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Updated: Jul 17, 2026
10:52
An Alkali-burn Injury Model of Corneal Neovascularization in the Mouse
Published on: April 7, 2014
Progressive corneal vascularization caused by graft-versus-host disease
1Ophthalmic Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran. Mahammadpour@yahoo.com
Cornea
|January 26, 2007
Summary
Graft-versus-host disease (GVHD) can cause severe dry eye and corneal vascularization in bone marrow transplant patients. Early diagnosis and treatment of ocular complications are crucial for preserving vision.
Area of Science:
- Ophthalmology
- Hematology
- Oncology
Background:
- Graft-versus-host disease (GVHD) is a common complication following allogeneic bone marrow transplantation.
- Ocular manifestations of GVHD can be severe and lead to significant visual impairment.
Observation:
- A 50-year-old male, post-allogeneic bone marrow transplant for acute myeloblastic leukemia, presented with decreased vision and photophobia.
- Ocular examination revealed severe dry eye disease, which progressed to corneal neovascularization despite medical management.
Findings:
- The patient's severe dry eye was refractory to standard treatments.
- Progressive corneal vascularization developed, indicating a serious ocular complication of GVHD.
Implications:
- Early and vigilant screening for dry eye in GVHD patients is essential.
- Prompt intervention for ocular GVHD may prevent irreversible corneal damage and vision loss.
- Multidisciplinary collaboration between ophthalmologists and oncologists is vital for optimal patient care and visual outcomes.
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