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Updated: Jul 17, 2026
08:31
Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia
Published on: October 17, 2025
Acute lymphoblastic leukemia presenting as acute renal failure
William M Suh1, Zev A Wainberg, Sven de Vos
1David Geffen School of Medicine at UCLA, Department of Medicine, 10833 Le Conte Avenue, Room 57-143, Los Angeles, CA 90095, USA. willsuh@gmail.com
Nature Clinical Practice. Nephrology
|January 26, 2007
Summary
A previously healthy man developed Bell's palsy and acute renal failure. Diagnosis revealed acute lymphoblastic leukemia, requiring chemotherapy and hemodialysis for tumor lysis syndrome.
Area of Science:
- Oncology
- Nephrology
- Neurology
Background:
- A 42-year-old male presented with acute headache and facial paralysis, initially treated as Bell's palsy.
- Following initial treatment, the patient developed acute renal failure, necessitating hospitalization.
Observation:
- Extensive investigations including biopsies and imaging were performed.
- Diagnoses included acute lymphoblastic leukemia, bilateral renal enlargement due to leukemic infiltration, acute renal failure, tumor lysis syndrome, and leukemic facial nerve involvement.
Findings:
- Treatment involved a modified induction chemotherapy regimen.
- Management included allopurinol for hyperuricemia and alkalized intravenous fluids to prevent uric acid nephropathy.
- Significant tumor lysis post-chemotherapy necessitated hemodialysis.
Implications:
- This case highlights the importance of considering systemic malignancy in patients presenting with unusual neurological and renal symptoms.
- Early diagnosis and aggressive management of acute lymphoblastic leukemia are crucial for patient outcomes.
- Understanding and managing tumor lysis syndrome is critical in the treatment of hematologic malignancies.
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