Fluorescein fundus angiographic findings in Vogt-Koyanagi-Harada syndrome

To report the fluorescein fundus angiographic (FFA) findings in the different clinical stages of Vogt-Koyanagi-Harada (VKH) patients.

Retrospective, transversal and descriptive study. All patients underwent FFA at least in one occasion. Patients with incomplete clinical files or a deficient FFA were excluded. We divided the patients in four groups, depending on their clinical stage at the time of the study: acute uveitic stage, chronic uveitis stage, convalescent stage and recurrence stage. We correlated the frequency and statistical significance of eleven angiographic patterns with their corresponding clinical stages.

The files of 60 patients were reviewed. Most common findings in the acute uveitis stage were: disseminated spotted choroidal hyperfluorescence and choroidal hypofluorescence. In the chronic uveitic stage: spotted hyper and hypofluorescence and optic disc hyperfluorescence. In the convalescent stage: spotted hyper and hypofluorescence and blockage of choroidal fluorescence. Retinal vasculitis was found more frequently than in previous reports. A reticular hypofluorescent pattern with no clinical correlation was found.

The angiographic findings of VKH syndrome change as the disease progress along different clinical stages. Recognition of those different patterns helps the clinician to diagnose the disease during all its stages.