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Prostasomes, angiogenesis, and tissue factor.

George H Delves1, Alistair B Stewart, Alan J Cooper

  • 1School of Biomedical Sciences, University of Portsmouth, Portsmouth, United Kingdom.

Seminars in Thrombosis and Hemostasis
|January 27, 2007
PubMed
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Prostasomes, vesicles from prostate cells, impact fertility and blood vessel growth (angiogenesis). Seminal prostasomes inhibit angiogenesis, while malignant prostate cell prostasomes promote it, likely via lipid transfer.

Area of Science:

  • Reproductive Biology
  • Oncology
  • Cell Biology

Background:

  • Prostasomes are secretory vesicles from prostate cells.
  • They contain proteins like tissue factor and are rich in cholesterol and sphingomyelin.
  • Prostasomes influence fertility, sperm motility, acrosome reaction, and immunosuppression.

Purpose of the Study:

  • To review evidence on prostasome effects on in vitro angiogenesis.
  • To elucidate the mechanism behind these angiogenic effects.
  • To differentiate effects of seminal vs. malignant prostate cell prostasomes.

Main Methods:

  • Review of existing literature on prostasomes and angiogenesis assays.
  • Analysis of heat treatment effects on prostasome function.
  • Focus on lipid composition, particularly sphingomyelin.

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Main Results:

  • Seminal prostasomes inhibit in vitro angiogenesis.
  • Prostasomes from malignant prostate cells promote in vitro angiogenesis.
  • Angiogenic effects are heat-stable, suggesting a role for lipids, especially sphingomyelin.

Conclusions:

  • Prostasomes play a dual role in angiogenesis, dependent on their origin.
  • Lipid transfer, particularly sphingomyelin, is a key mechanism in prostasome-mediated angiogenesis.
  • Further research into prostasome lipidomics is warranted.