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Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
Diverse synthesis of novel Bisterpyridines via Suzuki-type cross-coupling
Fu She Han1, Masayoshi Higuchi, Dirk G Kurth
1Functional Modules Group, Organic Nanomaterials Center, National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan.
Abstract:
A new protocol is presented for the synthesis of novel bisterpyridine derivatives using palladium-catalyzed Miyaura- and Suzuki-type cross-couplings as the key reactions. This protocol is quick, efficient, mild, and broadly applicable for the construction of versatile bisterpyridines by symmetric and unsymmetric introduction of various substituents in the pyridine rings as well as by tuning the spacers for bridging the two terpyridine moieties. [reaction: see text].
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Conformation
The simplest example of a diene is 1,3-butadiene, an acyclic conjugated π system. At room temperature, the molecule exists as a mixture of s-cis and s-trans conformers by virtue of rotation around the carbon–carbon single bond. Although the s-trans isomer is more stable, the...

