Related Experiment Video
Updated: Jul 17, 2026
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
Acrodermatitis paraneoplastica responding to topical PUVA treatment
Ayad E Abrou1, Jamie Hope, Diane Jackson-Richards
1Department of Dermatology, Henry Ford Hospital, Detroit, MI 48322, USA.
Photodermatology, Photoimmunology & Photomedicine
|January 27, 2007
Summary
Acrodermatitis paraneoplastica, a rare skin condition linked to cancer, was effectively treated with PUVA therapy. This approach offers a new treatment option for this challenging paraneoplastic syndrome.
Area of Science:
- Dermatology
- Oncology
Background:
- Acrodermatitis paraneoplastica is a rare paraneoplastic syndrome.
- It is most commonly associated with squamous cell carcinoma of the aerodigestive tract.
- Current therapies focus on treating the underlying malignancy.
Observation:
- A case of acrodermatitis paraneoplastica is presented.
- The patient's condition was refractory to standard treatments targeting the primary cancer.
Findings:
- Successful treatment of acrodermatitis paraneoplastica was achieved using PUVA (psoralen plus ultraviolet A) therapy.
- This highlights a potential therapeutic alternative beyond addressing the primary neoplasm.
Implications:
- PUVA therapy may be a viable treatment option for acrodermatitis paraneoplastica.
- Further research is warranted to explore the efficacy and mechanisms of phototherapy in managing this paraneoplastic dermatosis.
Related Concept Videos
01:27Acne Infection
Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
01:30Skin Cancer
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
01:23Skin Diseases and Disorders
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...