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Updated: Jul 17, 2026

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms
05:00

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms

Published on: March 3, 2021

Localized therapeutic hypothermia in the brain for the treatment of ischemic stroke

J Slotboom

    Journal of Applied Physiology (Bethesda, Md. : 1985)
    |January 27, 2007
    PubMed
    Abstract

    No abstract available in PubMed .

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    Ischemic Stroke ll: Pathophysiology01:15

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    An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

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