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Updated: Jul 17, 2026

High-Density Lipoprotein-Specific Phospholipid Efflux Assay
Published on: September 30, 2025
High-density lipoprotein cholesterol: an emerging target for stroke treatment
Nerses Sanossian1, Jeffrey L Saver, Mohamad Navab
1Department of Neurology, University of Southern California, Los Angeles, CA 90033, USA. sanossia@yahoo.com
Background And Purpose:
This review characterizes the current state of knowledge of high-density lipoprotein (HDL) in relation to stroke.
Summary Of Review:
HDL has anti-atherosclerotic and anti-inflammatory properties and is an important component in atherosclerosis. Serum HDL-cholesterol levels are inversely related to heart disease and stroke risk. There are various established and experimental treatments which can raise serum HDL cholesterol and improve its function.
Conclusions:
HDL is an emerging target for atherosclerotic stroke treatment with the potential to dramatically impact the care of stroke patients.
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