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Updated: Jul 17, 2026

A Next-generation Tissue Microarray (ngTMA) Protocol for Biomarker Studies
Published on: September 23, 2014
[The TNM system: only 3 letters for a rich but sometimes ambiguous language]
1Service d'Anatomie et de Cytologie Pathologiques, Hôpital du Haut Lévêque, CHU de Bordeaux, avenue de Magellan, 33604 Pessac Cedex. genevieve.belleannee@chu-bordeaux.fr
Abstract:
The T (tumor), N (node) and M (metastasis) staging system classifies tumors according to the anatomic extent. Since its first publication in 1940, the TNM classification has been periodically updated. This article reviews the main changes of the last edition and potential practical difficulties in interpretation of pN0 status, residual tumor, definition and classification of micrometastases and isolated tumoral cells, yTNM, use of X classification.
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