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Related Experiment Video

Updated: Jul 17, 2026

Stereotactic Radiosurgery for Gynecologic Cancer
10:35

Stereotactic Radiosurgery for Gynecologic Cancer

Published on: April 17, 2012

Image-guided robotic radiosurgery for spinal metastases.

Iris C Gibbs1, Pimkhuan Kamnerdsupaphon, Mi-Ryeong Ryu

  • 1Department of Radiation Oncology, Stanford University, Stanford, CA 94305-5847, USA. iris.gibbs@stanford.edu

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
|January 30, 2007
PubMed
Summary

Image-guided robotic radiosurgery, using the CyberKnife system, effectively treated spinal metastases in 74 patients. This advanced treatment was generally safe, offering symptom relief for most patients, including those previously irradiated.

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Area of Science:

  • Neurosurgery
  • Radiation Oncology
  • Medical Physics

Background:

  • Spinal metastases present a significant clinical challenge, often requiring advanced treatment modalities.
  • Previous radiation therapy can complicate treatment decisions for recurrent or persistent spinal tumors.

Purpose of the Study:

  • To evaluate the efficacy and safety of image-guided robotic radiosurgery for managing spinal metastases.
  • To assess treatment outcomes in patients with spinal metastases, including those with prior radiation exposure.

Main Methods:

  • A cohort of 74 patients with 102 spinal metastases were treated between 1996 and 2005 using the CyberKnife robotic radiosurgery system.
  • Doses of 16-25 Gy in 1-5 fractions were delivered, with patients followed clinically and radiographically.

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Last Updated: Jul 17, 2026

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  • The study included symptomatic patients, many of whom had received prior radiation therapy.

    • Main Results:

    • Robotic radiosurgery demonstrated significant effectiveness, with 84% of symptomatic patients experiencing symptom improvement or resolution.
    • The treatment was generally safe, with no treatment-related deaths observed.
    • Three patients developed treatment-related spinal injury, and predictors for this complication were not identified.

    Conclusions:

    • Image-guided robotic radiosurgery is an effective and safe treatment option for spinal metastases.
    • This approach is particularly valuable for patients with spinal metastases who have previously undergone radiation therapy.