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[Rheological behavior of blood substitutes with a perfluorocarbon base].

J Draffehn1, H Reichelt

  • 1Institut für Klinische Chemie und Hämatologie, Militärmedizinischen Akademie Bad Saarow.

Die Pharmazie
|November 1, 1991
PubMed
Summary

Blood substitute viscosity is crucial for microcirculation, especially for perfluorocarbon-based oxygen carriers. Studies show that the rheological behavior of these substitutes does not cause organic disorders.

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[The standardization of colloid osmotic pressure of blood substitutes with a perfluorocarbon base].

Die Pharmazie·1991

Area of Science:

  • Biomedical Engineering
  • Hematology
  • Materials Science

Background:

  • Oxygen transport in the body occurs in capillaries, necessitating blood substitutes with suitable flow characteristics for microcirculation.
  • Perfluorocarbon emulsions are investigated as oxygen carriers, requiring evaluation of their viscosity and deemulsification properties.

Purpose of the Study:

  • To assess the viscosity and rheological behavior of blood substitutes, particularly those based on perfluorocarbons.
  • To determine if the rheological properties of these substitutes are compatible with physiological conditions and avoid organic disorders.

Main Methods:

  • Viscosity measurements were performed on highly polymerized dextran solutions, perfluorocarbon emulsions (oxygen carriers), blood, and mixtures.
  • Colloid osmotic pressure was determined for the blood substitute components.

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Main Results:

  • The rheological behavior of the examined blood substitutes was analyzed.
  • Viscosity measurements indicated that the tested blood substitutes are suitable for circulation.

Conclusions:

  • Appropriate viscosity of blood substitutes is essential for effective oxygen uptake and delivery in microcirculation.
  • The studied perfluorocarbon-based blood substitutes exhibit rheological properties that do not induce organic disorders, suggesting their potential for clinical use.