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Serum adiponectin and renal dysfunction in men with type 2 diabetes
Julie Lin1, Frank B Hu, Gary Curhan
1Renal Division, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA. jlin11@partners.org
Diabetes Care
|January 30, 2007
Summary
Higher adiponectin levels are linked to lower odds of moderate kidney dysfunction in men with type 2 diabetes. This finding highlights adiponectin
Area of Science:
- Endocrinology and Metabolism
- Nephrology
- Inflammation Research
Background:
- Inflammation is a key factor in both chronic kidney disease and type 2 diabetes.
- Adiponectin, an anti-inflammatory protein, is typically lower in diabetic individuals but elevated in end-stage renal disease.
- The relationship between adiponectin and mild to moderate renal dysfunction in type 2 diabetes requires further investigation.
Purpose of the Study:
- To examine the association between serum adiponectin concentrations and renal dysfunction in men with type 2 diabetes.
- To determine if adiponectin levels correlate with estimated glomerular filtration rate (eGFR) in this population.
Main Methods:
- Cross-sectional analysis of 733 men with type 2 diabetes from the Health Professionals' Follow-Up Study.
- Renal dysfunction defined as eGFR <60 ml/min per 1.73 m(2) using the four-variable Modification of Diet in Renal Disease equation.
- Multivariate logistic regression analysis to assess the relationship between serum adiponectin and renal dysfunction.
Main Results:
- Serum adiponectin showed a positive correlation with age and a negative correlation with weight.
- Men with higher adiponectin levels (second quartile or greater, >10 microg/ml) had significantly reduced odds of renal dysfunction (OR 0.48; 95% CI 0.28-0.81).
- These findings remained consistent even after including serum lipids in the multivariate model.
Conclusions:
- Elevated serum adiponectin concentrations are associated with a lower likelihood of moderate renal dysfunction in men with type 2 diabetes.
- Adiponectin may play a protective role against the progression of kidney disease in diabetic individuals.
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