Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 17, 2026

Measurement & Analysis of the Temporal Discrimination Threshold Applied to Cervical Dystonia
10:05

Measurement & Analysis of the Temporal Discrimination Threshold Applied to Cervical Dystonia

Published on: January 27, 2018

Abnormal temporal discrimination threshold in patients with multiple system atrophy.

Chul H Lyoo1, Seung Yeob Lee, Tae Jin Song

  • 1Department of Neurology, Youngdong Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Movement Disorders : Official Journal of the Movement Disorder Society
|January 30, 2007
PubMed
Summary

Multiple system atrophy (MSA) patients exhibit impaired temporal discrimination threshold (TDT), impacting kinesthetic sensation and motor control. This heightened TDT correlates with bradykinesia, suggesting nigrostriatal pathway involvement in MSA.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Laboratory Assessment and Clinical Outlook for <i>Ex Vivo</i>-Produced Human Platelets and Megakaryocytes from Stem Cell Sources.

Annals of laboratory medicine·2026
Same author

Oncologic effect of preoperative endoscopic sphincterotomy in patients undergoing pancreaticoduodenectomy for ampulla of vater cancer.

Langenbeck's archives of surgery·2025
Same author

Rationale and Design of the Efficacy and Safety of a Patch-Type Cardiac Monitor for Diagnosing Paroxysmal Atrial Fibrillation in Embolic Stroke of Undetermined Source Patients with Left Atrial Enlargement (SOLO-ESUS): A Randomized Controlled Trial.

Cerebrovascular diseases (Basel, Switzerland)·2025
Same author

Dysbiosis of Bile Microbiota in Cholangiocarcinoma Patients: A Comparison with Benign Biliary Diseases.

International journal of molecular sciences·2025
Same author

Detection of the HLA-C*14:02:41 Allele via Next-Generation Sequencing.

HLA·2025
Same author

Head-to-Head Comparison of Tau and Amyloid Positron Emission Tomography Visual Reads for Differential Diagnosis of Neurodegenerative Disorders: An International, Multicenter Study.

Annals of neurology·2024

Area of Science:

  • Neuroscience
  • Sensory Physiology
  • Movement Disorders

Background:

  • Temporal discrimination threshold (TDT) is crucial for kinesthetic sensation and voluntary movement control.
  • Elevated TDT is observed in Parkinson's disease and dystonia, contributing to motor deficits.
  • The role of TDT in multiple system atrophy (MSA), a related neurodegenerative disorder, remains underexplored.

Purpose of the Study:

  • To investigate the integrity of TDT in de novo patients with MSA.
  • To determine the clinical significance of TDT abnormalities in MSA.
  • To explore the relationship between TDT and motor deficits in MSA.

Main Methods:

  • TDT was measured in the feet of 30 de novo MSA patients and 11 controls using four paradigms.
  • Motor function was assessed using the Unified Parkinson's Disease Rating Scale (UPDRS).

More Related Videos

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder
09:13

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder

Published on: April 22, 2015

Eye-Tracking Control to Assess Cognitive Functions in Patients with Amyotrophic Lateral Sclerosis
07:00

Eye-Tracking Control to Assess Cognitive Functions in Patients with Amyotrophic Lateral Sclerosis

Published on: October 13, 2016

Related Experiment Videos

Last Updated: Jul 17, 2026

Measurement &amp; Analysis of the Temporal Discrimination Threshold Applied to Cervical Dystonia
10:05

Measurement & Analysis of the Temporal Discrimination Threshold Applied to Cervical Dystonia

Published on: January 27, 2018

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder
09:13

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder

Published on: April 22, 2015

Eye-Tracking Control to Assess Cognitive Functions in Patients with Amyotrophic Lateral Sclerosis
07:00

Eye-Tracking Control to Assess Cognitive Functions in Patients with Amyotrophic Lateral Sclerosis

Published on: October 13, 2016

  • Cerebellar function was evaluated with the International Cooperative Ataxia Rating Scale (ICARS).

    • Main Results:

    • MSA patients demonstrated significantly higher TDT values compared to controls.
    • TDT values correlated with UPDRS Motor scores, independent of ICARS scores.
    • Bradykinesia, specifically assessed by UPDRS Motor subscores, showed a significant correlation with TDT.

    Conclusions:

    • Abnormal TDT is present in early-stage MSA, indicating impaired temporal sensory processing.
    • The correlation between TDT and bradykinesia suggests a link between sensory deficits and motor symptoms in MSA.
    • Findings suggest that damage to nigrostriatal dopaminergic and/or striatal neurons contributes to altered somatic sensory processing in MSA.