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Detection of the HLA-C*14:02:41 Allele via Next-Generation Sequencing
Seung Yeob Lee1,2, Hyun-Jung Choi3
1Department of Laboratory Medicine, Jeonbuk National University Medical School and Hospital, Jeonju, South Korea.
HLA
|February 17, 2025
Summary
A new Human Leukocyte Antigen (HLA) allele, HLA-C*14:02:41, has been identified. It differs from a known allele by a single nucleotide change, impacting genetic typing.
Area of Science:
- Immunogenetics
- Molecular biology
- Human Leukocyte Antigen (HLA) system
Background:
- The Human Leukocyte Antigen (HLA) system plays a crucial role in immune response and transplantation.
- Accurate HLA allele identification is vital for clinical applications, including disease association studies and organ transplantation.
- Genetic variations within HLA loci can lead to distinct functional or typing differences.
Purpose of the Study:
- To characterize a novel HLA allele, HLA-C*14:02:41.
- To detail the specific genetic difference distinguishing HLA-C*14:02:41 from previously identified alleles.
Main Methods:
- Sequence analysis of the HLA-C gene.
- Comparison of nucleotide sequences between the novel and known alleles.
Main Results:
- The novel allele HLA-C*14:02:41 was identified.
- This allele is differentiated from HLA-C*14:02:01:01 by a single synonymous nucleotide substitution at position c.606 (G>C).
Conclusions:
- The discovery of HLA-C*14:02:41 expands the known HLA allele repertoire.
- This finding highlights the importance of high-resolution typing to detect subtle genetic variations.
