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[Diffuse cerebrospinal gliomatosis. Case report].

Y Yamamoto1, T Tsuji, M Suga

  • 1Department of Neurological Surgery, Matsuyama Shimin Hospital.

Neurologia Medico-Chirurgica
|December 1, 1991
PubMed
Summary
This summary is machine-generated.

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This case study details a 65-year-old male with glioblastoma multiforme, a rare diffuse brain tumor. Autopsy revealed extensive glial tumor infiltration throughout the brain and spinal cord, highlighting diagnostic challenges.

Area of Science:

  • Neuro-oncology
  • Neuropathology
  • Radiology

Background:

  • Glioblastoma multiforme (GBM) is an aggressive primary brain tumor.
  • Gliomatosis cerebri (GC) is a rare subtype characterized by diffuse infiltration.
  • Early diagnosis and treatment of diffuse brain tumors remain challenging.

Observation:

  • A 65-year-old male presented with memory and gait disturbances.
  • Imaging revealed diffuse low-density areas and enhanced masses, later diagnosed as GBM.
  • Autopsy confirmed extensive, diffuse infiltration of glial tumor cells throughout the central nervous system.

Findings:

  • Needle biopsy confirmed glioblastoma multiforme.
  • The tumor showed subependymal infiltration and calcification.

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  • Microscopic examination revealed widespread glial tumor cell infiltration far exceeding gross findings.

    • Implications:

    • This case underscores the difficulty in diagnosing and assessing the true extent of diffuse gliomas like gliomatosis cerebri using standard imaging.
    • The findings emphasize the importance of integrating clinical, radiological, and pathological data for accurate diagnosis.
    • Understanding the diffuse nature of these tumors is crucial for developing effective treatment strategies.