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Related Experiment Videos

Piroxicam-natural polymers interactions.

H H el-Shattawy1, A I el-Sherbiny, M A Bayomi

  • 1Dept. of Pharmaceutics, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.

European Journal of Drug Metabolism and Pharmacokinetics
|January 1, 1991
PubMed
Summary

Piroxicam, an anti-inflammatory drug, binds strongly to natural polymers like gamma-globulin and albumin. This interaction, influenced by salt concentration, may affect the drug's pharmacological effects and bioavailability.

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Area of Science:

  • Pharmacology
  • Biochemistry
  • Physical Chemistry

Background:

  • Piroxicam is a widely used non-steroidal anti-inflammatory drug (NSAID).
  • Naturally occurring polymers can influence drug pharmacokinetics and pharmacodynamics.
  • Understanding drug-polymer interactions is crucial for optimizing drug efficacy and safety.

Purpose of the Study:

  • To characterize the interaction between piroxicam and natural polymers: gamma-globulin, bovine serum-albumin, bovine synovial fluid, and casein.
  • To determine the binding parameters and capacity of these polymers for piroxicam.
  • To investigate the influence of salt concentration on piroxicam-polymer binding and assess in-vivo bioavailability.

Main Methods:

  • Equilibrium dialysis to quantify piroxicam binding to polymers.

Related Experiment Videos

  • Spectrophotometry to determine piroxicam concentration.
  • Langmuir and Sandberg plots to analyze binding capacity and parameters (K and n).
  • In-vivo absorption study in healthy volunteers to compare piroxicam bioavailability with and without casein.

    • Main Results:

    • Piroxicam binding increased with polymer concentration.
    • Binding capacity order: synovial fluid < albumin < casein < gamma-globulin.
    • Two classes of binding sites were identified for piroxicam with gamma-globulin, albumin, and casein.
    • Increased salt concentration decreased piroxicam binding, suggesting ionic interactions.
    • In-vivo study indicated potential differences in piroxicam bioavailability in the presence of casein.

    Conclusions:

    • Piroxicam exhibits strong binding to natural polymers, with varying degrees of affinity.
    • The binding characteristics suggest ionic interactions play a role in piroxicam-polymer complex formation.
    • These interactions may significantly impact piroxicam's pharmacological activity and bioavailability.
    • Further research is warranted to elucidate the clinical implications of these findings.