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Updated: Jul 17, 2026

Modification and Functionalization of the Guanidine Group by Tailor-made Precursors
Published on: April 27, 2017
Molecular recognition of oxoanions based on guanidinium receptors
Pascal Blondeau1, Margarita Segura, Ruth Pérez-Fernández
1Institute of Chemical Research of Catalonia (ICIQ), 43007 Tarragona, Spain.
Abstract:
Guanidinium is a versatile functional group with unique properties. In biological systems, hydrogen-bonding and electrostatic interactions involving the arginine side chains of proteins are critical to stabilise complexes between proteins and nucleic acids, carbohydrates or other proteins. Leading examples of artificial receptors for carboxylates, phosphates and other oxoanions, such as sulfate or nitrate are highlighted in this tutorial review, addressed to readers interested in biology, chemistry and supramolecular chemistry.
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