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Related Experiment Videos

Experimental oncogene induced prostate cancer.

T C Thompson1, D Kadmon, T L Timme

  • 1Scott Department of Urology, Baylor College of Medicine, Houston, Texas 77030.

Cancer Surveys
|January 1, 1991
PubMed
Summary

This study uses a mouse prostate reconstitution model to investigate prostate cancer development. Researchers found that TGF-beta 1 and TGF-beta 3 expression influences tumor progression and is affected by castration.

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Area of Science:

  • Urology
  • Oncology
  • Developmental Biology

Background:

  • The mouse prostate reconstitution (MPR) model allows in vivo study of prostate cancer initiation and progression.
  • This model utilizes fetal urogenital sinus grafted under a mouse renal capsule to develop a mature prostate.

Purpose of the Study:

  • To investigate the roles of ras and myc oncogenes in distinct prostatic pathologies.
  • To explore the impact of genetic variance on tumor susceptibility.
  • To analyze the effect of castration on gene expression in prostate adenocarcinoma.

Main Methods:

  • Introduction of ras and myc oncogenes into fetal urogenital sinus via retroviral vectors.
  • Expanded MPR protocol for restricted infection of mesenchyme or epithelial compartments.

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  • Analysis of genetic variance in tumor induction between mouse strains.
  • Establishment of clonal prostate adenocarcinomas for castration studies.

    • Main Results:

    • Ras oncogene induced dysplasia, myc induced hyperplasia, and ras+myc induced carcinomas.
    • Genetic variance in tumor susceptibility was observed between mouse strains.
    • TGF-beta 1 and TGF-beta 3 were strongly associated with tumor progression.
    • Castration treatment further enhanced TGF-beta 1 and TGF-beta 3 mRNA levels in malignant adenocarcinomas.

    Conclusions:

    • TGF-beta 1 and TGF-beta 3 expression significantly influences prostate cancer progression.
    • The MPR model provides a flexible platform for fundamental prostate cancer research.
    • Findings may inform the development of more effective prostate cancer therapies.