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Indocyanine Green-Guided Intraoperative Imaging to Facilitate Video-Assisted Retroperitoneal Debridement for Treating Acute Necrotizing Pancreatitis
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Published on: September 8, 2022

[Pathogenesis and treatment of hemocoagulation disorders in an acute necrotic pancreatitis]

A A Pereiaslov, S M Chuklin, M M Posivnych

    Klinichna Khirurhiia
    |February 3, 2007
    PubMed

    Insights

    Investigating acute pancreatitis, researchers found that Intercellular Adhesion Molecule-1 (ICAM-1) and interleukin-18 (IL-18) levels rise while activated protein C decreases. These inflammatory markers correlate with hematocrit and inversely with protein C levels.

    Area of Science:

    • Biochemistry
    • Immunology
    • Clinical Medicine

    Context:

    • Acute pancreatitis is a serious inflammatory condition.
    • Biomarkers play a crucial role in understanding disease progression.
    • Activated protein C, ICAM-1, and IL-18 are implicated in inflammatory processes.

    Purpose:

    • To investigate the levels of activated protein C, ICAM-1, and IL-18 in patients with acute pancreatitis.
    • To determine the correlation between these biomarkers and clinical parameters like hematocrit.

    Summary:

    • Patients with acute pancreatitis showed elevated levels of Intercellular Adhesion Molecule-1 (ICAM-1) and interleukin-18 (IL-18) upon hospital admission.
    • A decrease in activated protein C levels was observed in these patients.
    • A significant positive correlation was found between serum IL-18 and ICAM-1 levels and hematocrit.
    • Conversely, a negative correlation was noted between these mediator concentrations and the level of activated protein C throughout the observation period.

    Impact:

    • This study identifies key inflammatory biomarkers for acute pancreatitis.
    • Understanding these biomarker dynamics can aid in patient monitoring and prognosis.
    • Findings may contribute to developing targeted therapeutic strategies for acute pancreatitis.

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