Optimisation of polyherbal gels for vaginal drug delivery by Box-Behnken statistical design
Shruti Chopra1, Sanjay K Motwani, Zeenat Iqbal
1Department of Pharmaceutics, Jamia Hamdard, New Delhi, India. shrutichopra21@yahoo.com
Abstract:
The present research work aimed at development and optimisation of mucoadhesive polyherbal gels (MPG) for vaginal drug delivery. As the rheological and mucoadhesive properties of the gels correlate well to each other the prepared MPGs were optimised for maximum mucoadhesion using a relationship between the storage modulus (G') and Gel Index (GI), by employing a 3-factor, 3-level Box-Behnken statistical design. Independent variables studied were the polymer concentration (X(1)), honey concentration (X(2)) and aerosil concentration (X(3)). Aerosil has been investigated for the first time to improve the consistency of gels. The dependent variables studied were the elastic modulus, G'(Y(1)), gel index (Y(2)), and maximum detachment force (Y(3)) with applied constraints of 500
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