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Updated: Jul 17, 2026

Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation
Published on: March 22, 2017
Pediatric surgeons and gastroesophageal reflux
Juan A Tovar1, Ana L Luis, Jose L Encinas
1Department of Pediatric Surgery, Hospital Universitario La Paz, 28046 Madrid, Spain. jatovar.hulp@salud.madrid.org
Fundoplication effectively controls reflux in children, especially those with specific comorbidities. While complications occurred, long-term wrap integrity and satisfactory functional results were achieved in most cases, highlighting its value in pediatric surgery.
Area of Science:
- Pediatric Surgery
- Gastrointestinal Surgery
- Surgical Outcomes
Background:
- The indications for pediatric fundoplication are evolving due to advancements in antacid medications and the advent of laparoscopy.
- This study reviews the indications, surgical approaches (open vs. laparoscopic), and outcomes of fundoplication in 252 refluxing children operated between 1992 and 2006.
Discussion:
- Laparoscopic fundoplication was more common in children with digestive, respiratory, or neurologic symptoms, while open surgery predominated for other comorbidities.
- Complication rates were higher with laparotomy (22% overall), emphasizing the need for careful surgical technique.
- The study discusses the long-term integrity of the fundoplicated wrap, analyzing success rates across different patient groups.
Key Insights:
- Overall wrap integrity was maintained in 89% of patients, with higher rates in symptom-based groups (95% digestive/respiratory) compared to complex comorbidities (e.g., 72% esophageal atresia).
- Functional results were satisfactory in 83% of cases, with a low operative mortality rate of 0.4%.
- Fundoplication remains a powerful tool for reflux control, particularly in symptomatic cases refractory to medical management or with specific comorbidities.
Outlook:
- The findings support fundoplication as a valuable surgical option for carefully selected pediatric patients with gastroesophageal reflux disease.
- Maintaining high technical standards and rigorous outcome reporting is crucial for the continued relevance of pediatric fundoplication.
- Further discussion is needed among pediatric surgeons to refine indications and optimize surgical approaches for this procedure.
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