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Related Experiment Videos

High-throughput cell manipulation using ultrasound fields.

Deok-Ho Kim1, Albrecht Haake, Yu Sun

  • 1Microsyst. Res. Center, Korea Inst. of Sci. & Technol., Seoul, South Korea.

Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
|February 3, 2007
PubMed
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This study introduces a new method for high-throughput cell manipulation using ultrasound waves to trap and move cells. The technique efficiently concentrates cells with minimal adverse effects, showing promise for lab-on-a-chip applications.

Area of Science:

  • Biotechnology
  • Acoustic manipulation
  • Cell biology

Background:

  • High-throughput cell manipulation is crucial for various biological applications.
  • Existing methods may face limitations in speed, efficiency, or cell viability.
  • Acoustic forces offer a non-invasive approach for cell handling.

Purpose of the Study:

  • To present a novel method for high-throughput cell manipulation using acoustic forces.
  • To demonstrate the efficacy of this technique for concentrating diverse cell types.
  • To assess the impact of ultrasound fields on cell viability.

Main Methods:

  • Utilizing acoustic forces within an ultrasound field to trap and transport biological cells in liquid.
  • Applying the technique to concentrate cell types including HeLa cells and human mesenchymal stem cells.

Related Experiment Videos

  • Investigating cell viability following exposure to ultrasound fields.

    • Main Results:

    • Achieved high-throughput trapping and transportation of biological cells.
    • Successfully concentrated over 90% of cells into desired patterns.
    • Observed minimal adverse effects on cell viability in ultrasound fields.

    Conclusions:

    • Ultrasonic cell manipulation is a viable technique for high-throughput cell handling.
    • The method is suitable for integration into lab-on-a-chip systems for rapid cell concentration and transportation.
    • This technology shows significant promise for applications in cell fractioning.