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Applying models of targeted drug delivery to gene delivery
1Biosystems Group, Department of Biopharmaceutical Sciences University of California, San Francisco, School of Pharmacy, CA 94143, USA.
Abstract:
Gene delivery requires targeted delivery systems. Exploratory simulations using models of targeted drug delivery helps one assess the worthiness of such systems, and helps quantify the expected therapeutic benefits of the systems. The drug targeting index (DTI), a ratio of availabilities, is a measure of pharmacokinetic benefit of the delivery device, based on a combination of a physiologically-based pharmacokinetic model and a single pharmacodynamic E
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