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Updated: Jul 17, 2026

A Wireless, Bidirectional Interface for In Vivo Recording and Stimulation of Neural Activity in Freely Behaving Rats

A Wireless, Bidirectional Interface for In Vivo Recording and Stimulation of Neural Activity in Freely Behaving Rats

Published on: November 7, 2017

Wireless multichannel biopotential recording using an integrated FM telemetry circuit.

P Mohseni¹, K Najafi

¹Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI 48109, USA.

Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

|February 3, 2007

Summary

This study presents a low-power wireless microsystem for multichannel biopotential recording. The system achieves high signal fidelity for neural spike detection, enabling advanced neurophysiological research.

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In vitro and in vivo testing of a wireless multichannel stimulating telemetry microsystem.

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Area of Science:

Biomedical Engineering
Neuroscience Instrumentation
Integrated Circuit Design

Background:

Advancements in neuroscience require sophisticated tools for capturing neural signals.
Existing systems often face limitations in power consumption, bandwidth, and wireless capabilities.
Miniaturized, low-power, and wireless recording systems are crucial for in vivo and in vitro neural monitoring.

Purpose of the Study:

To design, implement, and test a novel wireless multichannel recording microsystem.
To achieve high-fidelity biopotential recording with minimal power dissipation.
To validate the system's performance using simulated neural signals.

Main Methods:

Development of an integrated circuit (IC) with on-chip AC amplification, DC stabilization, and time-division-multiplexing.

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A Wireless, Bidirectional Interface for In Vivo Recording and Stimulation of Neural Activity in Freely Behaving Rats

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Non-restraining EEG Radiotelemetry: Epidural and Deep Intracerebral Stereotaxic EEG Electrode Placement

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Published on: June 25, 2016

Utilizing frequency modulation (FM) for wireless transmission of biopotential signals (0.05-6 kHz).

Fabrication of a 4.84 mm² IC using a 1.5 µm 2P2M CMOS process and interfacing with a micromachined silicon probe.

Main Results:

Measured input-output (I/O) correlation coefficients ranged from 70-94% per channel for spike train inputs (0.2-2 mVp-p).
The system achieved a low power dissipation of 2.2 mW from a 3 V supply.
Successful in vitro recording of simulated neural spikes at 98 MHz with I/O correlation coefficients exceeding 80%.

Conclusions:

The developed wireless multichannel recording microsystem offers a promising solution for low-power, high-fidelity neural signal acquisition.
The system's performance validates its potential for advanced neurophysiological studies.
Integration with micromachined probes enables simultaneous multichannel wireless recording, advancing neural interface technology.