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Related Experiment Video

Updated: Jul 17, 2026

Construction and Implantation of a Microinfusion System for Sustained Delivery of Neuroactive Agents.
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Construction and Implantation of a Microinfusion System for Sustained Delivery of Neuroactive Agents.

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Benzocyclobutene (BCB) based neural implants with microfluidic channel.

K Lee1, J He, L Wang

  • 1Arizona Biodesign Institute, Arizona State University, Tempe, AZ, USA.

Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
|February 3, 2007
PubMed
Summary

We developed flexible, biocompatible benzocyclobutene (BCB) neural implants with integrated microfluidics for delivering chemicals in animal models. These implants show promise for chronic neuroscience research applications.

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Area of Science:

  • Neuroscience
  • Biomaterials Science
  • Microfabrication Engineering

Background:

  • Intracortical neural implants are crucial for neuroscience research.
  • Existing implants face challenges with chronic applications, including biocompatibility and flexibility.
  • Microfluidic integration offers potential for targeted chemical delivery.

Purpose of the Study:

  • To fabricate and characterize benzocyclobutene (BCB) based intracortical neural implants with embedded microfluidic channels.
  • To evaluate the suitability of BCB implants for basic neuroscience research in animal models.
  • To assess the implant's performance in terms of mechanical stability, chemical delivery, and biocompatibility.

Main Methods:

  • Fabrication of single-shank implants using batch microfabrication technology with benzocyclobutene (BCB).

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  • Integration of a microfluidic channel with hydrophobic properties for chemical reagent delivery.
  • In vitro biocompatibility testing using cultured cells.
  • Mechanical testing involving penetration of rat's pia with a silicon backbone layer.
  • Electrochemical impedance measurements at 1 kHz.
  • Functional testing of water flow through the microfluidic channel.

    • Main Results:

    • Successfully fabricated BCB implants with integrated microfluidic channels, recording sites, and reservoirs.
    • Demonstrated excellent flexibility and biocompatibility with no observed toxic effects on cultured cells.
    • The implant, reinforced with a silicon backbone, penetrated the rat's pia without buckling.
    • Achieved an average impedance of 1.2 MΩ at 1 kHz.
    • Confirmed controlled fluid delivery through the microfluidic channel via syringe pumps.

    Conclusions:

    • Benzocyclobutene (BCB) based neural implants offer a promising platform for chronic neuroscience research due to their flexibility, biocompatibility, and manufacturability.
    • The integrated microfluidic channel enables controlled chemical reagent delivery, enhancing the utility of neural implants.
    • These findings support the potential of BCB implants for advancing in vivo neuroscience studies and therapeutic applications.