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The evolution of CellML.

P F Nielsen1, M D Halstead

  • 1Institute of Bioengineering, Auckland University, New Zealand.

Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
|February 3, 2007
PubMed
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CellML is an open XML-based language for biological models. Its flexible design allows for broader applications beyond cellular processes, with ongoing development of tools to support its use.

Area of Science:

  • Computational biology
  • Bioinformatics
  • Systems biology

Background:

  • CellML is an XML-based markup language designed for describing and exchanging mathematical models of biological processes.
  • Initially focused on cellular and subcellular processes, its core design principles are adaptable to a wider scope.

Purpose of the Study:

  • To describe the structure of CellML.
  • To explain how CellML is evolving to encompass a broader range of biological modeling.
  • To introduce tools being developed to aid CellML adoption and usage.

Main Methods:

  • Descriptive analysis of the CellML language structure.
  • Review of ongoing developments and extensions to CellML's scope.
  • Overview of supporting tools for CellML model creation and management.

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Main Results:

  • CellML's foundational design is robust and extensible.
  • The language is evolving to support more complex and diverse biological modeling needs.
  • A suite of tools is under development to enhance usability and accessibility.

Conclusions:

  • CellML's adaptable architecture facilitates its expansion beyond its original scope.
  • Continued development of CellML and its associated tools will promote wider adoption in biological modeling.
  • The language serves as a valuable standard for representing and sharing mathematical models in biology.