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Updated: Jul 17, 2026

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice
Published on: January 7, 2019
Estimation of ethanol infusion profile to produce specified BrAC time course using physiologically-based
M H Plawecki1, R A DeCarlo, V A Ramchandani
1Dept. of Biomedical Eng., Purdue Univ., West Lafayette, IN, USA.
Abstract:
A procedure for estimating the alcohol infusion profile required to produce a specific breath alcohol concentration (BrAC) time course using a PBPK model is described. Model parameter values are predicted from linear relationships to readily measurable physical characteristics or morphometrics. An algorithm to optimize this transformation, based upon recorded clinical experimental data, is provided. A substantial improvement in all error statistics, in relation to the original transform was obtained.
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