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Updated: Jul 17, 2026

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse
Published on: May 31, 2016
[Management of fatigue in oncology]
Jane Gledhill1, Cécile Boisvert, Chantal Thinlot
1Chargée de recherche en soins infirmiers, institut Gustave-Roussy, 94805 Villejuif Cedex.
Abstract:
Fatigue associated with cancer may be present at any stage of the disease; its characteristics vary depending on the type and the duration of treatment, the presence of side effects and the reactions from patients. Often associated with other symptoms (pain, nausea, vomiting, anxiety, stress etc.), fatigue affects the daily life of patients as much as or even more than pain. This multi-factored and annoying symptom is linked to physical, cognitive and affective functioning, which must be assessed (Piper fatigue scale). Beside the medical management, nursing research found four efficient interventions to reduce fatigue: educating patients and their families, programming physical conditioning and activities to restore the attention, improving diet, hydration and sleep. The pluridisciplinary management of this symptom is a key factor to a better quality of life.
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Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

