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Using or abusing: viruses and the cellular DNA damage response

Caroline E Lilley1, Rachel A Schwartz, Matthew D Weitzman

  • 1Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

Trends in Microbiology
|February 6, 2007
PubMed

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In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
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