Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Melatonin and the aging brain.

Stephen C Bondy1, Edward H Sharman

  • 1Center for Occupational and Environmental Health, Department of Community & Environmental Medicine, University of California, Irvine, CA 92697-1825, USA. scbondy@uci.edu

Neurochemistry International
|February 6, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Critical Role of Autophagy and Phagocytosis in the Aging Brain.

International journal of molecular sciences·2025
Same author

Mitochondrial Dysfunction as the Major Basis of Brain Aging.

Biomolecules·2024
Same author

The Hormesis Concept: Strengths and Shortcomings.

Biomolecules·2023
Same author

Melatonin and Aging.

Sub-cellular biochemistry·2023
Same author

Relationships between Diabetes and the Intestinal Microbial Population.

International journal of molecular sciences·2023
Same author

Electronic cigarette aerosol increases the risk of organ dysfunction by enhancing oxidative stress and inflammation.

Drug and chemical toxicology·2021
Same journal

Allopregnanolone reduces the blocking properties of competitive antagonists of GABA(A) receptor.

Neurochemistry international·2026
Same journal

Glial High-Mobility Group Box 1 Translocation Promotes Post-Stroke Epileptic Seizures.

Neurochemistry international·2026
Same journal

Mild Traumatic Brain Injury Produces Persistent Wake-State Instability and EEG Slowing Despite Carbon Monoxide Neuroprotection.

Neurochemistry international·2026
Same journal

Tanshinone IIA alleviates cerebral ischemia-reperfusion injury by inhibiting pyroptosis: involvement of the KLF4/CHIP/NLRP3 pathway.

Neurochemistry international·2026
Same journal

Attenuating effects of heat-processed Panax ginseng (Red and Black) on methamphetamine-induced behaviors via dopaminergic modulation.

Neurochemistry international·2026
Same journal

Mesenchymal stem cell secretome attenuates disease-associated microglial activation and cognitive decline in TBI-associated neuroinflammation.

Neurochemistry international·2026
See all related articles

Melatonin may slow brain aging and treat neurodegenerative diseases by reducing oxidative stress and inflammation. Its neuroprotective effects are linked to melatonin receptor activation, enhancing antioxidant defenses.

Area of Science:

  • Neuroscience
  • Gerontology
  • Pharmacology

Background:

  • Brain aging involves increased oxidative stress, inflammation, and mitochondrial dysfunction.
  • These factors are exacerbated in age-related neurological diseases, suggesting common therapeutic targets.
  • Melatonin has shown promise in preclinical models of neurodegeneration.

Purpose of the Study:

  • To review the role of melatonin in mitigating age-related brain changes.
  • To explore the mechanisms behind melatonin's neuroprotective effects.
  • To assess melatonin's potential for treating brain aging and neurodegenerative disorders.

Main Methods:

  • Literature review focusing on studies involving melatonin and brain aging/neurodegeneration.
  • Analysis of preclinical data from animal and cell culture models.

Related Experiment Videos

  • Examination of proposed molecular mechanisms of melatonin action.

    • Main Results:

    • Melatonin application in models shows neuroprotective benefits.
    • Key mechanisms include melatonin receptor activation, transcription factor modulation, and altered gene expression.
    • Enhanced antioxidant enzyme activity and reduced inflammation are observed.

    Conclusions:

    • Melatonin demonstrates potential for slowing normal brain aging.
    • It may serve as a therapeutic agent for neurodegenerative conditions.
    • Low cost and low toxicity further support its utility.